Venting, Air and Gas Filtration

 

はじめに

Pall filters for pharmaceutical air and gas service are optimized for use in prefiltration of compressed or pressurized gases, and sterile air or gas filtration to completely remove particles, droplets, microorganisms like molds, yeasts or bacteria and even viruses and phages.These filters also find wide use in negative pressure applications such as sterile filtration of vacuum break lines on lyophilizers and autoclaves, and sterile and non-sterile venting of tanks and containers.Pall filters for air and gas service are available in a range of proprietary -manufactured hydrophobic filter media, including PTFE and PVDF as well as glass fiber, polypropylene, cellulose and porous stainless steel.Pall air and gas filters can be sized to meet a wide range of flow and pressure drop requirements, from sterile venting in the laboratory to small process flows in pilot operations, from compressed air flows in process scale operations to full scale air supply in large scale aerobic fermentations at ambient or elevated temperatures.

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Venting, Air & Gas Applications

用途Why filtration is importantHow Pall Can Help
Sterile Venting of:Tanks, Vessels and Transport Containers, Autoclaves, Lyophilizers, Incubators, and Isolators 医薬品製造作業中の充填および排出操作により容器内の空気が内外に移動します。In most cases no airborne particles or microorganisms are allowed to enter critical product or water tanks. Pall エンフロン® PFR filters are hydrophobic sterile filters removing microorganisms, viruses and particles.They are integrity testable and validated, also for long-term use.For small scale applications that require SIP capability in a disposable capsule, the ノバシップ filter can be used.GMP compliant Pall Advanta® housings support high air flow rates for economic system design.
Sterile Filtration of Pressurized Air or Gas:Biotechnical Air Supply, Exhaust Air Filtration, Filling and Blow Fill Seal Operations, and Transport of Liquids Many pharmaceutical and biotechnological processes need pressurized air or gas as a basic requirement for optimized operation or cell growth.In most products and processes no particles or microorganisms are allowed to enter via air or gas supply lines whereas biohazardous organisms are not allowed to leave into the environment.
Sterile Filtration of High Flow Fermentor Air Supply 最大100 m3以上の大きな発酵装置では、効率の高い細胞増殖を可能にするためには、滅菌エアの流量が非常に高いことが必要です。Historically, large glass fiber towers or multiple narrow bore cartridges have been used. Wide bore エンフロン® sterile filters provide flow rates of up to 5000 Nm3/h/cartridge (3000 SCFM/cartridge).主な利点は、システムサイズが小さいこと、資本コストが低いこと、使いやすいことです。これらのフィルターは、完全性の検証が可能で、機能を満載したタワーや従来のマルチカートリッジ滅菌エアフィルターに代わって使用できる経済的、安全、かつ効率的なフィルターであることがバリデーションで確認されています。プレフィルターも、長い寿命と圧力損失の低減のために使用できます。
Venting and Sterile Filtration of Pressurized Air or Gas in Extreme Environments Some processes in the biopharmaceutical industry that needs sterile air filtration or venting operations are running at higher temperatures.標準の材料が極端な環境条件に対応していない場合、プロセスの安全性に影響が及ぶ可能性があります。 Special air filter elements like エンフロン® CFR filters with improved material resistance are able to provide safety and long service lives in environments with higher temperatures or elevated oxidation stress.

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